Antithrombotic actions of statins involve PECAM-1 signaling

Antithrombotic actions of statins involve PECAM-1 signaling.

Statins are widely prescribed cholesterol-lowering drugs that are a first-line treatment of coronary artery disease and atherosclerosis, reducing the incidence of thrombotic events such as myocardial infarction and stroke. Statins have been shown to reduce platelet activation, although the mechanism(s) through which this occurs is unclear. Because several of the characteristic effects of statin...

Hydrogen sulfide exerts antithrombotic effects and inhibits deep vein thrombosis through NOS-PECAM-1 signaling pathway

Deep vein thrombosis (DVT) is initiated in aggregation and adhesion of inflammatory cells to vascular endothelium mediated by adhesion molecules, thereby activating platelets and inducing thrombosis. Hydrogen sulfide (H2S) is a gasotransmitter with anti-adhesive, anti-inflammatory and vasoactive properties. This study aimed to investigate the inhibitory effect of platelet aggregation and thromb...

Statins as antithrombotic drugs.

Statins as Antithrombotic Drugs Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.112.145334 2013;127:251-257 Circulation. http://circ.ahajournals.org/content/127/2/251 World Wide Web at: The online ve...

PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a tyrosine phosphoprotein highly expressed on endothelial cells and leukocytes, is an important component in the regulation of neutrophil transendothelial migration. Engagement of endothelial PECAM-1 activates tyrosine phosphorylation events and evokes prolonged calcium transients, while homophilic engagement of neutrophil PECAM-1 ac...

TLR4 Signaling in Macrophages PECAM-1 Ligation Negatively Regulates